The accumulation of non-enzymatic modifications on both DNA and protein molecules under
the attack of reactive oxygen species (ROS), is one of the most possible factors responsible
for the functional deterioration in aged cells. Direct protein modifications as well as DNA
damages may be detectable, in part, by proteome analysis if the gene expression is affected
by the damages on DNA. The novel term “proteome”, which is a compound of “protein” and
“genome”, means a whole set of proteins expressed in a tissue or a cell strain to be …